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Short Syntheses of 4-Deoxycarbazomycin B, Sorazolon E, and (+)-Sorazolon E2
Makoto Sako1, Kazuya Ichinose1, Shinobu Takizawa1
1The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki-shi, Osaka, 567-0047, Japan.
Chemistry, an Asian Journal
|April 19, 2017
Abstract:
Short syntheses of 4-deoxycarbazomycin B and sorazolon E were established through the condensation of cyclohexanone and commercially available 4-methoxy-2,3-dimethylaniline, followed by PdII -catalyzed dehydrogenative aromatization/intramolecular C-C bond coupling and deprotection. A chiral dinuclear vanadium complex (Ra ,S,S)-6 mediated the enantioselective oxidative coupling of sorazolon E, affording (+)-sorazolon E2 in good enantioselectivity.