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Current trends in quantitative proteomics - an update.

H Li1, J Han1, J Pan1

  • 1University of Victoria - Genome British Columbia Proteomics Centre, University of Victoria, Victoria, BC, V8Z 7X8, Canada.

Journal of Mass Spectrometry : JMS
|April 19, 2017
PubMed
Summary
This summary is machine-generated.

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Advancements in quantitative proteomics offer new tools for protein biomarker discovery and disease diagnostics. This review covers innovative methods for protein quantification, enhancing biological insights.

Area of Science:

  • Biochemistry
  • Proteomics
  • Biotechnology

Background:

  • Proteins offer functional insights and are promising biomarker candidates.
  • Protein quantification is crucial for disease diagnosis and treatment monitoring.
  • Despite challenges in large-scale quantification, technological advancements are ongoing.

Purpose of the Study:

  • To review innovative methods in quantitative proteomics.
  • To discuss current and potential applications of these new technologies.
  • To update a previous review from 2009 on quantitative proteomics trends.

Main Methods:

  • Review of novel derivatization reagents.
  • Analysis of new sampling formats.
  • Discussion of advanced analyzers and scanning techniques.
Keywords:
OrbitrapSWATHmass spectrometryproteomicsquantitationstandardization

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  • Inclusion of software for assay development and data analysis.

    • Main Results:

    • A wider selection of tools for quantitative proteomics is now available compared to 2009.
    • New technologies facilitate more effective protein quantification in complex samples.
    • Innovative methods expand the potential applications in proteomics.

    Conclusions:

    • Quantitative proteomics has significantly evolved with new technologies.
    • These advancements improve the utility of proteins as biomarkers.
    • The field is poised for further innovation in protein analysis and application.