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The TERT rs2736100 polymorphism increases cancer risk: A meta-analysis
1Department of Microbiology and Immunology, Medical School of Jishou University, Jishou 416000, Hunan, China.
The TERT rs2736100 polymorphism is linked to a higher risk of developing various cancers. This genetic variation in the telomerase reverse transcriptase gene increases overall cancer risk, confirmed by a large meta-analysis.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Abnormal telomerase activity is a known factor in cancer development.
- The rs2736100 T > G polymorphism in the telomerase reverse transcriptase (TERT) gene is a potential cancer risk factor.
Purpose of the Study:
- To conduct a meta-analysis to precisely assess the association between the TERT rs2736100 polymorphism and overall cancer risk.
- To investigate the association of this polymorphism with specific cancer types.
Main Methods:
- A comprehensive literature search of PubMed and EMBASE databases was performed up to November 1, 2016.
- A meta-analysis included 61 articles comprising 72 studies with 108,248 cases and 161,472 controls.
- Stratified analyses were conducted based on cancer type.
Main Results:
- The TERT rs2736100 polymorphism was significantly associated with increased overall cancer risk across five genetic models.
- Specific cancer types, including thyroid, bladder, lung, glioma, myeloproliferative neoplasms, and acute myeloid leukemia, showed an elevated risk associated with the polymorphism.
- Odds ratios ranged from 1.16 to 1.39, with P-values < 0.001 for all models.
Conclusions:
- The TERT rs2736100 polymorphism is confirmed to confer an increased overall cancer risk.
- This genetic variation is associated with elevated risk for several specific cancer types, highlighting its role in cancer etiology.
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