Native aortic valve thrombosis in patient with protein S deficiency

Native aortic valve thrombosis is an extremely rare condition, the causes of which include previous aortic valve diseases, endocarditis, valvular injury by a catheter intervention and an underlying hypercoagulative state. Its diagnosis is important for preventing life-threatening embolic complications. Here, we report a case of native aortic valve thrombosis and recurrent systemic embolism in a patient with protein S deficiency, a disorder associated with a hypercoagulative state.