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Adjunctive Corticosteroid Therapy in the Treatment of Coccidioidal Meningitis
George R Thompson1,2, Janis E Blair3, Sharon Wang2
1Department of Medical Microbiology and Immunology.
Abstract:
Coccidioidal meningitis (CM) has high morbidity, and adjunctive measures to improve outcomes are needed. Using an established multicenter retrospective cohort study of CM (N = 221), we found that patients receiving adjunctive corticosteroids had a significant reduction in secondary cerebrovascular events (P = .0049). Those with CM-associated cerebrovascular events (8%) may benefit from short-term corticosteroids.