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Related Experiment Videos

Intrinsic neural activity differences among psychotic illnesses.

Matthew E Hudgens-Haney1, Lauren E Ethridge2,3, Justin B Knight1

  • 1Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens, Georgia.

Psychophysiology
|April 19, 2017
PubMed
Summary

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Inconsistent baseline adjustments may explain differing brain responses in psychosis. This study identified distinct psychosis biotypes with opposing neural activity, despite similar cognitive performance.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Individuals with psychosis exhibit variable brain responses, potentially due to inconsistent baseline adjustments.
  • Understanding neural activity differences in psychosis requires accounting for baseline levels.

Purpose of the Study:

  • To investigate the relationship between neural activity and cognitive demands in psychosis.
  • To explore how baseline adjustments impact the interpretation of neural responses in psychosis.
  • To identify distinct psychosis subgroups (biotypes) based on neurobiological features.

Main Methods:

  • Utilized a pro/antisaccade task with steady-state stimuli.
  • Assessed neural activity during baseline and task preparation in 98 psychosis probands.
Keywords:
EEGbiomarkersbipolar disorderdiagnosispsychosisschizophreniasteady-state

Related Experiment Videos

  • Subgrouped probands into biotypes using brain-based biomarkers, independent of symptoms.

    • Main Results:

    • Psychosis probands generally showed impaired antisaccade performance and reduced baseline phase synchrony.
    • Distinct biotypes exhibited varied behavioral and neural measures, aligning with predictions.
    • Two biotypes had similar deficits but opposite neural activity amplitudes; one biotype resembled healthy controls.

    Conclusions:

    • Baseline neural activity and synchrony are crucial for understanding psychosis.
    • Distinct psychosis biotypes display reduced or augmented intrinsic neural activity, irrespective of clinical presentation.