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Conversion of Pregabalin to 4-Isobutylpyrrolidone-2
Amanda M Drachnik1, Harshita Kumari2, Collin M Mayhan1
1Department of Chemistry, University of Missouri-Columbia, 601 S. College Avenue, Columbia, Missouri 65211.
Journal of Pharmaceutical Sciences
|April 19, 2017
Abstract:
Solid-state studies of C-butyl-resorcin[4]arene with pregabalin (Lyrica, Nervalin) in nitrobenzene yielded a cocrystal of C-butyl-resorcin[4]arene with 4-isobutylpyrrolidone-2. A combined experimental and quantum chemical investigation was implemented to further our understanding of the factors affecting the conversion process.