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Related Experiment Videos

Liver tumours.

P P Anthony

    Bailliere'S Clinical Gastroenterology
    |April 1, 1988
    PubMed
    Summary
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    Drug-induced liver tumors are rare in humans, with sex steroids and anabolic-androgenic steroids posing the main risks. Early removal of these liver tumors is recommended due to rupture complications.

    Area of Science:

    • Hepatology
    • Toxicology
    • Oncology

    Background:

    • Human resistance to carcinogens contrasts with rodent susceptibility, particularly for liver tumors.
    • Understanding drug-induced liver neoplasia in humans is limited despite extensive animal studies.

    Purpose of the Study:

    • To review the evidence for drug-induced liver tumors in humans.
    • To assess the risks associated with specific drug classes and their impact on liver vasculature.

    Main Methods:

    • Literature review of drug-induced liver tumors.
    • Analysis of epidemiological data and case reports.
    • Evaluation of the role of sex steroids, anabolic-androgenic steroids, and thorium dioxide.

    Main Results:

    Keywords:
    BiologyCancerContraceptionContraceptive AgentsContraceptive Agents, FemaleContraceptive Methods--side effectsDiseasesFamily PlanningHepatic EffectsLiver Neoplasms--etiologyNeoplasmsOral Contraceptives--side effectsPhysiologyPopulation At RiskResearch MethodologyRisk Factors

    Related Experiment Videos

    • Few drugs cause liver tumors in humans; risk is generally low.
    • C17-alkylated/ethinylated steroids (oral contraceptives) are linked to liver cell adenomas, with controversial links to carcinoma.
    • Anabolic-androgenic steroids are associated with peliosis and adenomas, not carcinomas.
    • Thorium dioxide remains a risk for angiosarcoma, liver cell carcinoma, and bile duct carcinoma.

    Conclusions:

    • Drug-induced liver neoplasia is a relatively minor clinical side effect.
    • Vascular effects of steroids necessitate surgical removal of liver tumors to prevent hemorrhage.
    • Continued vigilance is needed for thorium dioxide-exposed individuals.