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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Cancers·2021
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Related Experiment Video

Updated: Jun 23, 2026

Chronic Salmonella Infected Mouse Model
09:01

Chronic Salmonella Infected Mouse Model

Published on: May 31, 2010

Utilizing Salmonella to treat solid malignancies.

Nancy D Ebelt1, Edwin R Manuel1

  • 1Department of Experimental Therapeutics, Beckman Research Institute of City of Hope, Duarte, California.

Journal of Surgical Oncology
|April 19, 2017
PubMed
Summary
This summary is machine-generated.

Salmonella bacteria can be engineered to target and destroy pancreatic cancer cells. This novel approach offers a promising new strategy for treating pancreatic ductal adenocarcinoma (PDAC).

Keywords:
bacterial vectorsimmune suppressionimmunotherapyindoleamine 2,3-dioxygenasepancreatic cancer

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Last Updated: Jun 23, 2026

Chronic Salmonella Infected Mouse Model
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Published on: May 31, 2010

Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria
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Published on: July 6, 2013

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Area of Science:

  • Oncology
  • Microbiology
  • Biotechnology

Background:

  • Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a poor prognosis.
  • Surgical resection offers the best survival chance, but recurrence rates are high.
  • Systemic treatments have advanced from cytotoxic chemotherapy to targeted agents.

Purpose of the Study:

  • To review the potential of using Salmonella bacteria as a therapeutic agent against solid tumors.
  • To highlight Salmonella's capacity for tumor colonization and elimination.

Main Methods:

  • Review of existing research on Salmonella-based cancer therapy.
  • Analysis of Salmonella's inherent tumor-targeting and killing mechanisms.

Main Results:

  • Salmonella demonstrates inherent tumor-colonizing capabilities.
  • Engineered Salmonella can effectively eliminate solid tumors.

Conclusions:

  • Salmonella-based therapy represents a promising novel strategy for pancreatic cancer treatment.
  • This approach could overcome limitations of current systemic treatments for PDAC.