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[Inhibitory effect of interferons and tumor necrosis factor on syncytium formation by bovine leukemia virus]
1Département de Microbiologie, Université Médicale de la Préfecture de Kyoto, Japan.
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1987
Abstract:
The treatments of the bovine spleen cells BESp with recombinant human leukocyte interferon (HuIFN-alpha A) and human fibroblast interferon (HuIFN-beta) inhibit the syncytium formation by bovine leukemia virus (BLV) and the virus yield, depending on the IFN doses. But HuIFN-gamma did not inhibit the syncytium formation. The tumor-necrosis factor (TNF) also inhibits the syncytium formation and the virus yield, depending on the TNF doses. Furthermore, the combination of the HuIFN-alpha A with the TNF inhibits the syncytium formation more strongly than the HuIFN-alpha A alone or the TNF alone.