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Direct electron spin resonance evidence for alpha-tocopherol-induced phase separation in model membranes
1Dipartimento di Fisica dell'Università di Perugia, Italy.
Chemistry and Physics of Lipids
|June 1, 1988
Abstract:
The high resolution (narrow linewidth) amphiphilic spin probe perdeutero di-t-butyl nitroxide (PDDTBN) has been used to investigate the effect of alpha-tocopherol on lecithin liposomes. The electron spin resonance (ESR) results obtained as a function both of alpha-tocopherol concentration and of temperature indicate the presence of two different hydrophobic sites for the spin probe molecules. The presence of two distinct phases, one alpha-tocopherol-poor and the other alpha-tocopherol-rich, is suggested in these phospholipid bilayers.