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Tranexamic Acid Controlled Chronic Disseminated Intravascular Coagulation Associated with Aortic Dissection and
Yodo Gatate1, Nobuyuki Masaki1, Atsushi Sato1
1Department of Cardiology, National Defense Medical College, Japan.
Insights
The study successfully treated chronic disseminated intravascular coagulation (DIC) in aortic dissection using tranexamic acid. This antifibrinolytic agent stabilized coagulation and reduced bleeding for three years.
Area of Science:
- Cardiology
- Hematology
- Pharmacology
Background:
- Chronic disseminated intravascular coagulation (DIC) management in aortic dissection remains undefined.
- Systemic hemorrhage control is crucial even after surgical aortic dissection repair.
Observation:
- A patient with aortic dissection and a patent false lumen experienced acute exacerbation of chronic DIC.
- Treatment involved oral tranexamic acid (1,500 mg/day) and periodic heparin for hemodialysis.
Findings:
- Tranexamic acid stabilized coagulative and fibrinolytic parameters effectively.
- Bleeding tendencies were relieved without adverse effects.
- The positive outcome persisted for up to three years.
Implications:
- Tranexamic acid offers a potential therapeutic strategy for managing chronic DIC associated with aortic dissection.
- This approach may improve bleeding control and patient outcomes in complex cardiovascular cases.
- Further research is warranted to confirm the efficacy and safety of tranexamic acid in similar conditions.
Abstract:
The management of chronic disseminated intravascular coagulation (DIC) caused by aortic dissection has not yet been established. Even in cases where surgical correction is performed, therapeutic control of systemic hemorrhaging is still required. We herein report the successful treatment of a case of aortic dissection with a patent false lumen using tranexamic acid for acute exacerbation of chronic DIC. Oral administration of 1,500 mg tranexamic acid per day stabilized the coagulative and fibrinolytic parameters and relieved bleeding tendencies with no side effects. Heparin was administered periodically for the management of hemodialysis. This favorable result continued for up to 3 years.