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Adenomyomatosis Concomitant with Primary Gallbladder Carcinoma
Tatsuya Morikawa1, Takehiro Okabayashi, Yasuo Shima
1Department of Gastroenterological Surgery, Kochi Health Sciences Center, Kochi 781-8555, Japan.
Acta Medica Okayama
|April 20, 2017
Summary
Gallbladder adenomyomatosis (ADM) may coexist with early gallbladder cancer (GB cancer), complicating diagnosis. Clinicians should consider this association due to the difficulty in detecting malignancy preoperatively.
Area of Science:
- Gastroenterology
- Surgical Pathology
- Oncology
Background:
- Gallbladder adenomyomatosis (ADM) is a benign condition.
- A potential link between ADM and gallbladder (GB) cancer has been suggested.
- ADM is not typically considered to have malignant potential.
Purpose of the Study:
- To investigate the coexistence of ADM and GB cancer.
- To evaluate the diagnostic challenges in cases of concurrent ADM and GB cancer.
- To raise awareness among clinicians about this association.
Main Methods:
- Retrospective review of surgical pathology database.
- Analysis of 624 gallbladder resections from March 2005 to May 2015.
- Pathological classification of 93 ADM cases (fundal, segmental, diffuse types).
Main Results:
- Early-stage GB cancer was detected in 3.2% (3/93) of ADM resections.
- Preoperative imaging did not suggest malignancy in these cases.
- GB cancer developed in association with fundal-type and segmental-type ADM.
Conclusions:
- Early diagnosis of GB cancer is challenging when ADM is present.
- Clinicians must be aware of the frequent coexistence of ADM and GB cancer.
- Further vigilance is required for patients with ADM.