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Measurement of Heme Synthesis Levels in Mammalian Cells
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Heme as a Target for Therapeutic Interventions.

Stephan Immenschuh1, Vijith Vijayan1, Sabina Janciauskiene2

  • 1Institute for Transfusion Medicine, Hannover Medical SchoolHannover, Germany.

Frontiers in Pharmacology
|April 20, 2017
PubMed
Summary

Free heme is essential but toxic at high levels, contributing to diseases like sickle cell and sepsis. Hemopexin (Hx) and heme oxygenase-1 (HO-1) regulate heme, offering therapeutic potential.

Keywords:
hemeheme oxygenasesheme toxicityhemolysishemopexininflammationinflammatory diseases

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