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The outer membrane vesicles: Secretion system type zero.

Andrea Guerrero-Mandujano¹, Cecilia Hernández-Cortez², Jose Antonio Ibarra³

¹Laboratorio de Bacteriología Médica, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, México.

Traffic (Copenhagen, Denmark)

|April 20, 2017

Summary

Outer membrane vesicles (OMVs) in Gram-negative bacteria are proposed as a novel secretion system. These vesicles transport diverse biomolecules, highlighting their potential role in bacterial survival and communication.

Keywords:

bacteria outer membrane vesicles secretion system virulence factor

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Area of Science:

Microbiology
Bacterial Physiology
Molecular Biology

Background:

Gram-negative bacteria utilize various secretion systems (Types 1-6) for survival.
Outer membrane vesicles (OMVs) are increasingly recognized for their role beyond structural components.

Purpose of the Study:

To evaluate outer membrane vesicles (OMVs) as a potential independent secretion system in Gram-negative bacteria.
To describe the advantages of biomolecule transport via OMVs.

Main Methods:

Characterization of OMVs based on their origin and composition.
Analysis of the types of biomolecules transported by OMVs.

Main Results:

OMVs are spherical particles (50-250 nm) derived from the outer membrane.
OMVs carry a diverse cargo including enzymes, toxins, antigenic determinants, and nucleic acids.

Conclusions:

OMVs exhibit characteristics of a distinct secretion system.
The transport capabilities of OMVs suggest a significant role in bacterial intercellular communication and adaptation.