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Unusual biochemistry of changes in neuron membrane permeability evoked by cAMP
E A Liberman1, S V Minina, O L Myakotina
1Institute for Information Transmission Problems, Acad. Sci. USSR, Moscow.
FEBS Letters
|August 29, 1988
Abstract:
Influence of different metabolic poisons on cAMP-evoked neuron membrane permeability is investigated. Drugs preventing cAMP binding with R subunits of protein kinase decrease the cAMP-evoked current, but the inhibitor of the C subunit. H8, has no effect. The cAMP-dependent current is increased by uncouplers and decreased by inhibitors of glycolysis and oxidative phosphorylation. The mechanism of cAMP action on neuron permeability is discussed.