Related Experiment Video
Updated: Aug 11, 2026

09:37
Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
[A tumour mistaken for a scar]
1Amphia Ziekenhuis, afd. Dermatologie, Breda.
Nederlands Tijdschrift Voor Geneeskunde
|April 20, 2017
Summary
Dermatofibrosarcoma protuberans (DFSP), a rare and aggressive skin cancer, requires timely diagnosis. Histopathology is key for identifying DFSP and enabling prompt treatment to prevent recurrence.
Area of Science:
- Oncology
- Dermatology
- Pathology
Background:
- Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous soft tissue sarcoma.
- DFSP is characterized by local aggressiveness and a high recurrence rate, despite rare metastasis.
- Clinical presentation can be variable, leading to diverse differential diagnoses.
Observation:
- A 50-year-old male presented with a long-standing, painful scar on his back.
- A biopsy was performed, and histopathological examination confirmed the diagnosis of DFSP.
- The patient was referred to a specialized center for rare skin malignancies.
Findings:
- Histopathological examination is the definitive diagnostic method for suspected DFSP.
- DFSP exhibits clinical heterogeneity, complicating initial diagnosis.
- Prompt and accurate diagnosis is crucial for effective management.
Implications:
- Timely diagnosis of DFSP is essential due to its aggressive nature and high recurrence potential.
- Radical excision is the preferred treatment modality for DFSP.
- Early detection and appropriate treatment can improve patient outcomes and reduce the risk of recurrence.
Related Concept Videos
Cancer
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Clinical Applications of Epidermal Stem Cells
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Healing II: Complications
Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

