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A decrease in blood cholesterol after gastrostomy could impact survival in ALS.

H Blasco^1,2, F Patin^1,2, S Molinier²

¹UMR INSERM U930, Equipe Neurogénétique et Neurométabolomique, Université François Rabelais, Tours, France.

European Journal of Clinical Nutrition

|April 20, 2017

Summary

This summary is machine-generated.

Gastrostomy in amyotrophic lateral sclerosis (ALS) patients significantly decreased blood cholesterol levels. This preliminary study suggests a need to restore normal lipid metabolism in ALS patients undergoing gastrostomy.

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Last Updated: Mar 4, 2026

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Area of Science:

Neurology
Biochemistry

Background:

Gastrostomy is beneficial for amyotrophic lateral sclerosis (ALS) patients.
The impact of gastrostomy on biological parameters in ALS is not well understood.

Purpose of the Study:

To evaluate changes in biological parameters in ALS patients after gastrostomy.
To explore the relationship between these biological changes and disease progression.

Main Methods:

Retrospective analysis of clinical and biological data from 44 ALS patients.
Data collected at three time points: before, during, and after gastrostomy.
Examination of variations in total cholesterol and low-density lipoprotein cholesterol.

Main Results:

Significant differences in total cholesterol concentrations were observed before and after gastrostomy (P=0.0044).
Post-gastrostomy decreases in total cholesterol and LDL cholesterol were negatively associated with patient survival (P=0.0002).
Patients fed primarily via gastrostomy showed reduced blood cholesterol levels.

Conclusions:

Gastrostomy in ALS patients leads to decreased blood cholesterol.
Restoration of normal lipid metabolism should be considered for ALS patients receiving gastrostomy.