Inducible epitope imprinting: 'generating' the required binding site in membrane receptors for targeted drug delivery
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Sha Liu1, Qiuyan Bi, Yingying Long
1College of Pharmaceutical Sciences, Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, Southwest University, Chongqing 400715, China. chongli@swu.edu.cn.
Nanoscale
|April 20, 2017
Abstract:
We report an inducible epitope imprinting strategy that as a template, a flexible peptide chain can have a disordered-to-ordered conformational change by suitable inducement through a molecular imprinting procedure, and the formed nanoparticles can, in turn, remold the original peptide into the expected conformation and specifically bind to the corresponding protein.