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Regulatory T cells: tolerance induction in solid organ transplantation.
T Vaikunthanathan1, N Safinia1, D Boardman1
1MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, London, UK.
Clinical and Experimental Immunology
|April 20, 2017
Summary
Regulatory T cell (Treg) therapy is now a reality for transplantation. Understanding Treg biology and optimizing Treg immunotherapy are crucial for advancing transplantation tolerance in ongoing clinical trials.
Area of Science:
- Immunology
- Transplantation Science
- Cellular Therapy
Background:
- Regulatory T cells (Tregs) are critical for immune homeostasis.
- Advances in isolation and expansion technologies enable Treg therapy.
- Clinical trials are investigating Treg safety and efficacy in transplantation.
Purpose of the Study:
- To review current knowledge of Treg biology.
- To explore novel technologies for Treg immunotherapy.
- To address prerequisites for clinical Treg application in transplantation.
Main Methods:
- Literature review of Treg biology and immunotherapy.
- Analysis of current Treg-based clinical trials.
- Discussion of technological advancements in Treg expansion and application.
Main Results:
- Treg therapy is feasible in human transplant recipients.
- Several Phase I/II trials are actively investigating Treg therapy.
- Optimization of Treg therapy is essential for achieving transplantation tolerance.
Conclusions:
- Treg therapy represents a significant advancement in transplantation.
- Continued research into Treg biology and technology is vital.
- Successful clinical application of Tregs hinges on understanding their complex biology and optimizing immunotherapy strategies.