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Is mean platelet volume a better biomarker in pre-eclampsia?
Gustavo Vilchez1, Moraima Lagos2, Komal Kumar3
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Missouri, Kansas City School of Medicine, Kansas City, Missouri, USA.
The Journal of Obstetrics and Gynaecology Research
|April 20, 2017
Summary
Mean platelet volume (MPV) is a more significant biomarker for pre-eclampsia than platelet count. This finding aids in diagnosing pre-eclampsia, especially during the intrapartum period.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Clinical Diagnostics
Background:
- Pre-eclampsia is characterized by platelet activation and destruction.
- Existing literature presents conflicting data on the role of mean platelet volume (MPV) in pre-eclampsia diagnosis.
- The diagnostic utility of MPV compared to other laboratory markers requires further investigation, particularly during the intrapartum period.
Purpose of the Study:
- To evaluate mean platelet volume (MPV) as a diagnostic biomarker for pre-eclampsia.
- To compare the significance of MPV against routine laboratory markers, such as platelet count, in identifying pre-eclampsia.
- To assess the role of MPV in the intrapartum period of pregnancy.
Main Methods:
- Retrospective comparison of biochemical and hematological markers, including MPV, between pre-eclampsia cases and matched controls.
- Independent t-tests were used to compare laboratory marker data.
- Logistic regression and receiver operating characteristic (ROC) curve analyses were employed to assess the diagnostic strength of MPV and platelet count.
Main Results:
- A total of 150 pre-eclampsia cases and 297 controls were analyzed.
- Mean platelet volume (MPV) was significantly higher in the pre-eclampsia group (11.3 ± 1.0 fL) compared to controls (10.1 ± 0.8 fL, P = 0.002).
- Multivariate analysis identified MPV as the sole statistically significant biomarker for pre-eclampsia (OR, 4.5) and severe pre-eclampsia (OR, 6.2), outperforming platelet count.
Conclusions:
- Mean platelet volume (MPV) demonstrates greater significance as a biomarker for pre-eclampsia compared to platelet count.
- MPV shows a stronger association with pre-eclampsia than other routinely measured laboratory markers.
- Further evaluation of MPV's clinical utility in pre-eclampsia assessment is recommended, given its routine availability in complete blood cell counts.