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Ascorbic acid deficiency in patients with lichen planus.

Ilinca Nicolae1, Cristina Iulia Mitran1, Madalina Irina Mitran1

  • 1a Department of Dermatology , Clinical Hospital of Infectious Diseases Dr. Victor Babes , Bucharest , Romania.

Journal of Immunoassay & Immunochemistry
|April 20, 2017
PubMed
Summary

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Patients with lichen planus (LP) have significantly lower ascorbic acid levels, which decrease with age and increase with infections. This vitamin deficiency may indicate infection risk in LP patients.

Area of Science:

  • Dermatology
  • Biochemistry
  • Nutritional Science

Background:

  • Oxidative stress is implicated in the pathogenesis of lichen planus (LP).
  • Ascorbic acid (vitamin C) is a key antioxidant with potential relevance in LP.
  • Understanding ascorbic acid status in LP patients is crucial for managing the condition.

Purpose of the Study:

  • To investigate ascorbic acid levels in patients with lichen planus (LP).
  • To identify factors influencing ascorbic acid levels in LP patients.
  • To assess the potential of ascorbic acid status as an indicator for infection risk in LP.

Main Methods:

  • Urinary ascorbic acid levels were measured using a reflectometric method.
  • The study included 77 patients with LP (49 cutaneous LP, 28 oral LP) and 50 healthy controls.
Keywords:
ascorbic acidinfectionlichen planusoxidative stress

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  • Clinical examinations and laboratory tests were performed on all participants.

    • Main Results:

    • Ascorbic acid levels were significantly lower in both cutaneous LP (8.47 mg/dl) and oral LP (8.04 mg/dl) patients compared to controls (19.82 mg/dl).
    • A negative correlation was observed between ascorbic acid levels and age in LP patients (r = -0.318, p = 0.032).
    • LP patients with associated infections exhibited lower urinary ascorbic acid concentrations than those without infections.

    Conclusions:

    • Reduced urinary ascorbic acid levels are characteristic of lichen planus patients.
    • Ascorbic acid deficiency in LP correlates with age and the presence of infections.
    • Urinary ascorbic acid levels may serve as a biomarker for identifying LP patients at risk of infections.