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Updated: Aug 21, 2026
Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
Association between ALDH2 Glu487Lys polymorphism and the risk of esophageal cancer
Kang Liu1, Guiqin Song, Xiaoyan Zhu
1aInstitute of Tissue Engineering and Stem Cells, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital bBiotherapy Center, Nanchong Central Hospital cDepartment of Biology, North Sichuan Medical College dDepartment of Parasitology laboratory, Nanchong Central Hospital eDepartment of chest surgery, the Affiliated Hospital of North Sichuan Medical College fThe 2011 grade clinic medicine of North Sichuan Medical College gThe 2013 grade clinic medicine of North Sichuan Medical College, Nanchong, Sichuan Province, PR China.
Objective:
A meta-analysis was carried out to further evaluate the relationship between ALDH2 Glu487Lys polymorphism and esophageal cancer risk.
Methods:
A total number of 15 studies that included 3812 cases and 7376 controls were identified for our meta-analysis.
Results:
Our findings indicated that individuals with the combination of Glu/Lys and Lys/Lys genotype had an increased risk of getting esophageal cancer (GA + AA vs. GG: odds ratio [OR] 1.36, 95% confidence interval [CI] 0.93-2.00, P = 0.113) with a shift pattern. Although Lys/Lys genotype carriers showed areduced esophageal cancer risk (AA vs. GA + GG: OR 0.41, 95% CI 0.23-0.72, P = 0.002). Similarly, a negative association was observed under homozygote comparison (AA vs. GG: OR 0.49, 95% CI 0.29-0.85, P = 0.011). In the China subgroup analysis, the similar results were found.
Conclusions:
This meta-analysis concluded that there was a strong association between ALDH2 Glu487Lys polymorphism and the risk of esophageal cancer. It further confirmed that ALDH2 Glu487Lys polymorphism was a high-risk factor for esophageal cancer.
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