Related Experiment Videos
Relation between serum myokines and phase II cardiac rehabilitation
Der-Sheng Han1, Ming-Yen Hsiao, Tyng-Guey Wang
1aDepartment of Physical Medicine and Rehabilitation bCommunity and Geriatric Medicine Research Center, National Taiwan University Hospital Beihu Branch, Taipei, Taiwan cDepartment of Physical Medicine and Rehabilitation dDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan eResearch Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan fDepartment of Physical Medicine and Rehabilitation, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan.
Abstract:
Patients with coronary heart disease or acute myocardial infarction after cardiac catheterization with stenting referred for phase II cardiac rehabilitation (CR) were grouped according to their preference. Cardio-pulmonary exercise testing (CPET) was used to determine oxygen uptake ((Equation is included in full-text article.)) at peak exercise and anaerobic threshold (AT). The control patients received counseling only while the experiment group received 36 sessions of CR in 3 to 6 months. Exercise physiology parameters and serum myokines (myostatin, insulin-like growth factor-1 (IGF-1), and interleukin-6 (IL-6) were measured pre- and postrehabilitation.There were 29 patients in the experiment group and 10 in the control group, with no significant differences in baseline parameters. The experiment group had prominent progress in aerobic capacity and body composition after CR, but their serum myokine concentrations did not change significantly. Serum myostatin is positively correlated to peak (Equation is included in full-text article.)pre- and post-training, and pretraining AT (Equation is included in full-text article.), after adjusting for age, sex, and body composition. Serum IGF-1 is positively correlated with grip strength before training.Serum myostatin level is positively correlated to aerobic capacity, and IGF-1 level is positively correlated to grip strength in cardiac patients receiving CR.