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Cytomegalovirus peritonitis after kidney transplantation diagnosed through histopathological examination
Kiyohiko Hotta1, Yuichiro Fukasawa2, Yoshiki Wada1
1Department of Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan.
Abstract:
Among organ transplant recipients, cytomegalovirus (CMV) commonly results in various types of infection such as pneumonitis, hepatitis, and enterocolitis. However, CMV peritonitis is very rare and difficult to diagnose owing to lack of visible clinical signs. We present a case of a 35-year-old female kidney recipient who developed abdominal pain and urinary retention caused by CMV peritonitis. To our knowledge, this is the first case report of CMV peritonitis after organ transplantation to be diagnosed through histopathological examination.
Insights
Cytomegalovirus (CMV) peritonitis is a rare complication in organ transplant recipients. This case report details its diagnosis in a kidney recipient through histopathology, highlighting a novel diagnostic approach for this uncommon condition.
Area of Science:
- Transplant medicine
- Infectious diseases
- Gastroenterology
Background:
- Cytomegalovirus (CMV) infections are common in organ transplant recipients, manifesting as various conditions like pneumonitis, hepatitis, and enterocolitis.
- CMV peritonitis is an exceptionally rare presentation of CMV infection post-transplantation.
- Diagnosis of CMV peritonitis is challenging due to the absence of specific clinical indicators.
Observation:
- A 35-year-old female kidney transplant recipient presented with abdominal pain and urinary retention.
- These symptoms were attributed to CMV peritonitis, a rare complication.
- The diagnosis was confirmed via histopathological examination of peritoneal tissue.
Findings:
- This case represents the first reported instance of CMV peritonitis following organ transplantation diagnosed through histopathological examination.
- Histopathology proved crucial in identifying CMV peritonitis when clinical signs were ambiguous.
- The study underscores the utility of histopathology in diagnosing rare post-transplant infections.
Implications:
- This case expands the understanding of CMV manifestations in immunosuppressed patients.
- It highlights the importance of considering CMV peritonitis in transplant recipients with unexplained abdominal symptoms.
- Histopathological examination should be considered a key diagnostic tool for rare CMV presentations in this population.