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Related Experiment Videos

Predictive analysis of long non-coding RNA expression profiles in diffuse large B-cell lymphoma.

Danxia Zhu1, Cheng Fang1, Xiaodong Li1

  • 1Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China.

Oncotarget
|April 21, 2017
PubMed
Summary

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NAALADL2-AS2 functions as a competing endogenous RNA to regulate apoptosis and drug resistance in DLBCL.

Cancer biology & therapy·2024

This study identifies novel long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) dysregulated in diffuse large B-cell lymphoma (DLBCL). These findings highlight potential new targets for DLBCL research and therapeutic strategies.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Long non-coding RNAs (lncRNAs) play a role in various cancers.
  • Diffuse large B-cell lymphoma (DLBCL) requires further investigation for novel therapeutic targets.

Purpose of the Study:

  • To identify differentially expressed lncRNAs and messenger RNAs (mRNAs) in DLBCL.
  • To explore the regulatory networks involving lncRNAs in DLBCL progression.

Main Methods:

  • Genome-wide lncRNA expression analysis using Agilent lncRNA Chip system.
  • Validation of lncRNA expression via quantitative reverse transcription polymerase chain reaction (qRT-PCR).
  • Bioinformatic analyses including gene ontology, pathway analysis, and co-expression network construction (Cytoscape).
Keywords:
diffuse large B cell lymphomalong noncoding RNAsmicroarray

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Main Results:

  • 1053 lncRNAs and 4391 mRNAs were found to be dysregulated in DLBCL cell lines compared to normal B cells.
  • Key pathways implicated in DLBCL progression include cell cycle, apoptosis, B cell receptor, and NF-κB signaling.
  • Identification of transcription factor-lncRNA-target gene regulatory networks.

Conclusions:

  • A set of differentially expressed lncRNAs in DLBCL has been identified.
  • These lncRNAs are potentially involved in the regulation of critical cellular processes and signaling pathways in DLBCL.
  • The study provides a foundation for further investigation into lncRNAs as potential biomarkers or therapeutic targets for DLBCL.