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Updated: Mar 4, 2026

Transcranial Pulse Stimulation for Alzheimer's Patients
Published on: April 4, 2025
Supporting Simple Activity Engagement in Persons With Moderate to Severe Alzheimer's Disease Through a
Giulio E Lancioni1, Nirbhay N Singh2, Mark F O'Reilly3
11 Department of Neuroscience and Sense Organs, University of Bari, Bari, Italy.
Objectives:
These 2 studies assessed a technology-aided program to support mild physical exercise or simple occupational activity in participants with moderate to severe Alzheimer's disease.
Methods:
Study 1 included 11 participants who were to perform a leg-raising response. Study 2 included 10 participants who were to sort objects into different containers. The program ensured that they received positive stimulation contingent on the responses and reminders/prompts after periods of nonresponding. Each study was carried out according to a nonconcurrent multiple baseline design across participants.
Results:
The program was successful in supporting mild physical exercise and activity with objects in the 2 groups of participants, respectively. The participants also showed signs of positive involvement (eg, smiles and verbalizations) during the sessions. Moreover, staff personnel rated the program and its impact positively.
Conclusion:
The program may be considered a practical resource for supporting positive engagement in persons with moderate to severe Alzheimer's disease.
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