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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

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Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

497
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
497
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

499
 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
499
Arteries of Lower Limbs01:20

Arteries of Lower Limbs

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The external iliac artery transitions out of the body cavity, entering the femoral region of the lower leg, and is renamed the femoral artery at the point where it traverses the body wall. This artery is responsible for the distribution of blood to the thigh's deep muscles and the skin's ventral and lateral regions, achieved through several minor branches and the lateral deep femoral artery, which also spawns a lateral circumflex artery. The knee area receives blood from the genicular...
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Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

480
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
480

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Related Experiment Video

Updated: Mar 4, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
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Arterial stiffness in hematologic malignancies.

Ioana Mozos1, Georgiana Borzak2, Alexandru Caraba3

  • 1Department of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy.

Oncotargets and Therapy
|April 21, 2017
PubMed
Summary
This summary is machine-generated.

Hematologic malignancies significantly increase arterial stiffness through treatments like chemotherapy and stem cell transplant. This review highlights mechanisms and calls for cardiovascular screening in cancer survivors.

Keywords:
arterial stiffnesschemotherapycomplete blood countleukemialymphomamultiple myeloma

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Area of Science:

  • Cardiology
  • Hematology
  • Oncology

Background:

  • Cardiovascular disorders and malignant conditions are leading global causes of mortality.
  • Arterial stiffness is an independent predictor of cardiovascular events.

Purpose of the Study:

  • To review the literature linking hematologic malignancies and arterial stiffness.
  • To explore the mechanisms and clinical implications of this association.

Main Methods:

  • Literature review of experimental and clinical studies.
  • Analysis of data connecting complete blood count parameters with arterial stiffness in hematologic malignancies.

Main Results:

  • Hematologic malignancies are associated with increased arterial stiffness.
  • Chemotherapy (anthracyclines, cyclophosphamide, TKIs), radiotherapy, and stem cell transplantation are key contributors.
  • Mechanisms include oxidative stress, endothelial dysfunction, inflammation, and accelerated atherosclerosis.

Conclusions:

  • Arterial stiffness is a significant concern in hematologic malignancies.
  • Cardiovascular health screening and risk stratification are crucial for survivors.
  • Improving cardiovascular care can enhance prognosis and quality of life for patients.