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Related Experiment Video

Updated: Jun 28, 2026

Neural Tube Closure in Mouse Whole Embryo Culture

Neural Tube Closure in Mouse Whole Embryo Culture

Published on: October 21, 2011

Neural tube defects: Risk factors and preventive measures.

Atsuo Kondo¹, Takuya Matsuo², Nobuhito Morota³

¹Department of Urology, Atsuta Rehabilitation Hospital, Nagoya, Japan.

Congenital Anomalies

|April 21, 2017

Summary

This summary is machine-generated.

Folic acid prevents neural tube defects. Despite recommendations, Japan

Keywords:

Folic acid Mandatory fortification Neural tube defects Prevention Risk factors

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Area of Science:

Obstetrics and Gynecology
Public Health
Pediatrics

Background:

Neural tube defects (NTDs) are preventable with periconceptional folic acid administration.
Over 80 countries fortify staple foods with folic acid, significantly reducing NTD prevalence.
Japan recommends folic acid supplementation and provides educational materials, yet NTD rates remain unchanged.

Purpose of the Study:

To discuss risk factors for neural tube defects.
To propose preventive strategies for reducing NTDs in neonates.
To advocate for mandatory folic acid fortification of staple foods in Japan.

Main Methods:

Literature review on folic acid and NTD prevention.
Analysis of current Japanese public health initiatives regarding folic acid.
Discussion of risk factors and proposed interventions.

Main Results:

Folic acid fortification is a proven strategy for NTD prevention globally.
Japanese public health efforts have not demonstrably reduced NTD prevalence.
Continued high prevalence suggests a need for more effective interventions.

Conclusions:

Mandatory folic acid fortification of staple foods is crucial for Japan.
Fortification will decrease neonatal mortality and morbidity.
Implementing fortification will reduce the economic burden on the healthcare system.