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A Highly Active Manganese Catalyst for Enantioselective Ketone and Ester Hydrogenation
Magnus B Widegren1, Gavin J Harkness1, Alexandra M Z Slawin1
1School of Chemistry, University of St Andrews, EaStCHEM, St Andrews, Fife, KY16 9ST, UK.
Angewandte Chemie (International Ed. in English)
|April 21, 2017
Abstract:
A new hydrogenation catalyst based on a manganese complex of a chiral P,N,N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol % catalyst loading, and gives up to 97 % ee in the hydrogenation of pro-chiral deactivated ketones at 30-50 °C.