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Polyhydroxyalkanoate-associated phasins as phylogenetically heterogeneous, multipurpose proteins.

Beatriz Maestro1, Jesús M Sanz1

  • 1Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Av. Universidad s/n, Elche, 03202, Spain.

Microbial Biotechnology
|April 21, 2017
PubMed
Summary

Polyhydroxyalkanoates (PHAs) are biopolyesters produced by prokaryotes for energy storage. Phasins, key proteins covering PHA granules, are crucial for structure and metabolism, offering biotechnological potential.

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Area of Science:

  • Biotechnology
  • Microbiology
  • Polymer Science

Background:

  • Polyhydroxyalkanoates (PHAs) are natural polyesters synthesized by prokaryotes as carbon and energy reserves.
  • PHAs accumulate as intracellular inclusion bodies called 'carbonosomes', enclosed by a proteinaceous layer of granule-associated proteins (GAPs).
  • GAPs include metabolic enzymes and phasins, small proteins essential for granule structure and PHA metabolism.

Purpose of the Study:

  • To summarize the characteristics of identified phasins from PHA-producing organisms.
  • To highlight the biotechnological opportunities presented by phasins.

Main Methods:

  • Literature review of identified phasins.
  • Analysis of phasin structural and functional characteristics.

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  • Exploration of biotechnological applications.

    • Main Results:

    • Phasins are amphiphilic proteins that coat PHA granules, shielding the hydrophobic polymer.
    • They play a critical role in PHA granule structure and metabolic regulation.
    • Diverse phasins have been identified across various PHA-producing microorganisms.

    Conclusions:

    • Phasins are vital components of PHA granules with significant structural and regulatory roles.
    • Their unique properties offer diverse and promising opportunities for biotechnological applications.