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Results of the STOP-Hypertension-2 Trial

Lennart Hansson1

  • 1a Clinical Hypertension Research, Department of Public Health and Social Services, University of Uppsala, 751 25 Uppsala, Sweden.

Blood Pressure
|April 21, 2017
PubMed

Insights

Newer blood pressure drugs, including ACE inhibitors and calcium antagonists, showed similar cardiovascular benefits as older treatments in elderly patients. Lowering blood pressure effectively is key for preventing heart events in older adults.

Area of Science:

  • Cardiology
  • Geriatrics
  • Pharmacology

Background:

  • Elderly hypertensive patients require effective treatments to reduce cardiovascular risks.
  • Established therapies like beta-blockers and diuretics are common, but newer options like ACE inhibitors and calcium antagonists are also widely used.

Purpose of the Study:

  • To compare the cardiovascular mortality and morbidity of newer antihypertensive therapies (ACE inhibitors, calcium antagonists) versus established therapies (beta-blockers, diuretics) in elderly hypertensive patients.
  • To evaluate the safety and tolerability of these different treatment groups.

Main Methods:

  • The second Swedish Trial in Old patients with Hypertension (STOP-Hypertension-2) randomized 6614 elderly hypertensive patients.
  • Patients received conventional treatment, ACE inhibitors, or calcium antagonists for a mean of 5 years.
  • Primary endpoint: fatal stroke, myocardial infarction, or other fatal cardiovascular disease. Secondary endpoints included fatal/non-fatal stroke/myocardial infarction and other cardiovascular mortality.

Main Results:

  • All three treatment groups achieved similar reductions in supine systolic blood pressure.
  • No significant differences in the risk of major cardiovascular events were observed between newer and conventional therapies.
  • All antihypertensive regimens were well tolerated by the elderly participants.

Conclusions:

  • Blood pressure reduction is beneficial for elderly hypertensive patients, regardless of the specific therapy used.
  • The findings support current guidelines emphasizing achieved blood pressure reduction for cardiovascular event prevention.
  • Newer antihypertensive agents demonstrate comparable efficacy and safety to established treatments in this population.

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