Neutrophilic Figurate Erythema.

Area of Science:

• Dermatology
• Pathology

Background:

• Neutrophilic figurate erythema (NFE) is infrequently documented.
• Understanding its distinct clinical and histopathological features is crucial for accurate diagnosis.

Purpose of the Study:

• To identify and characterize the clinical and pathological features of Neutrophilic figurate erythema (NFE).

Main Methods:

• Retrospective review of diagnostic cases from 2000 to 2013.
• Diagnosis based on clinical presentation (annular rash), histopathology (neutrophilic infiltrate without vasculitis), and exclusion of other entities.

Main Results:

• Fifteen cases (11 female, 4 male; age 18-66) were identified.
• Common presentations included blistering annular erythema, purpuric annular erythema with vesicles, and annular rash with central scales.
• Histopathology revealed papillary dermal edema and leukocytoclasis; 10 patients experienced recurrent episodes.

Conclusions:

• NFE presents with distinct clinical and histopathological features, differentiating it from erythema annulare centrifugum.
• Pathologists should consider NFE in neutrophil-mediated inflammatory disorders.
• Antineutrophil therapy may be required for symptom management.