Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

784
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
784
Nephrons01:10

Nephrons

7.7K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
7.7K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

821
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
821
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

4.0K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
4.0K
Renal Corpuscle01:20

Renal Corpuscle

8.1K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
8.1K
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

1.4K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementation of the AAMATES Platform as a National Registry for Stage 5 CKD in Mexico.

Kidney medicine·2026
Same author

Dying on the waitlist: Mexico's kidney allocation system as a public health scandal.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Kidney Disease and Heart Failure: Recent Advances and Current Challenges: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

JACC. Heart failure·2026
Same author

Kidney disease and heart failure: recent advances and current challenges: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kidney international·2026
Same author

Neutrophil:lymphocyte ratio and cell-free DNA dynamics during excessive heat stress in occupational and experimental settings.

Journal of thermal biology·2026
Same author

Kidney Biopsy in Patients With Mechanical Ventilation: A Report of Ten Cases.

Kidney medicine·2026

Related Experiment Video

Updated: Mar 3, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

786

Pathophysiologic insight into MesoAmerican nephropathy.

Magdalena Madero1, Fernando E García-Arroyo, Laura-Gabriela Sánchez-Lozada

  • 1Department of Nephrology, INC Ignacio Chavez, Mexico City, Mexico.

Current Opinion in Nephrology and Hypertension
|April 21, 2017
PubMed
Summary

Mesoamerican nephropathy (MeN), a chronic kidney disease (CKD) in sugarcane workers, is caused by heat stress and dehydration. Understanding these risk factors is crucial for managing this devastating condition.

More Related Videos

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

1.0K
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

22.3K

Related Experiment Videos

Last Updated: Mar 3, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

786
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

1.0K
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

22.3K

Area of Science:

  • Nephrology
  • Environmental Health
  • Occupational Medicine

Background:

  • Mesoamerican nephropathy (MeN) is an emerging cause of chronic kidney disease (CKD) in Central America, primarily affecting sugarcane workers.
  • Unlike traditional CKD, MeN is not associated with diabetes or hypertension, presenting a unique etiological challenge.
  • Thousands of deaths in the region underscore the severity and public health impact of this condition.

Purpose of the Study:

  • This review aims to elucidate the risk factors and probable mechanisms underlying the initiation and progression of Mesoamerican nephropathy.
  • To provide a comprehensive overview of the current understanding of MeN pathogenesis.
  • To identify potential targets for intervention and prevention strategies.

Main Methods:

  • Literature review of studies investigating Mesoamerican nephropathy.
  • Analysis of pathophysiological pathways implicated in CKD development.
  • Synthesis of evidence linking environmental and occupational exposures to kidney injury.

Main Results:

  • Recurrent subclinical acute kidney injury, driven by heat stress, dehydration, and strenuous labor, is identified as a primary risk factor for MeN.
  • Chronic activation of the vasopressin, renin-angiotensin-aldosterone system, and polyol-fructokinase pathway in the kidneys is implicated.
  • Subclinical rhabdomyolysis, nephrotoxin exposure, high fructose intake, and NSAID use may exacerbate disease progression.

Conclusions:

  • Evidence strongly suggests that repeated cycles of heat stress, dehydration, and strenuous work contribute to CKD development.
  • The chronic activation of these pathways may explain the ineffectiveness of current CKD management strategies in halting disease progression.
  • Understanding these non-traditional risk factors is critical for developing effective treatments and preventive measures for MeN.