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Related Experiment Video

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Functional Manipulation of Maternal Gene Products Using In Vitro Oocyte Maturation in Zebrafish
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Dynamic regulation of Pin1 expression and function during zebrafish development.

Maria Solange Ibarra1, Carla Borini Etichetti1, Carolina Di Benedetto1

  • 1Instituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Rosario, Argentina.

Plos One
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Summary

Prolyl isomerase Pin1 regulates cell signaling and has roles in disease. This study reveals Pin1

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Developmental Biology

Background:

  • Prolyl isomerase Pin1 modulates proline-directed phosphorylation signaling.
  • Pin1 has diverse roles in physiological and pathological processes, including cancer and neurodegenerative diseases.
  • In vivo regulation of Pin1 expression and activity remains largely unknown.

Purpose of the Study:

  • To investigate the in vivo regulation and function of Pin1 during vertebrate development.
  • To elucidate the spatiotemporal expression patterns and subcellular localization of Pin1 in zebrafish.
  • To analyze the consequences of Pin1 overexpression in a living organism.

Main Methods:

  • Utilized Danio rerio (zebrafish) as a vertebrate model.
  • Analyzed pin1 mRNA and protein expression patterns during embryogenesis.
  • Investigated Pin1 subcellular distribution in various cell types and developmental stages.
  • Examined Pin1 expression in the adult zebrafish brain.
  • Assessed developmental alterations and apoptosis following Pin1 overexpression.

Main Results:

  • Pin1 expression is tightly regulated during zebrafish embryogenesis, establishing specific mRNA and protein distributions.
  • Distinct subcellular localization patterns of Pin1 were observed in specific cell types and developmental stages.
  • Pin1 overexpression in zebrafish led to developmental abnormalities and induced p53-dependent apoptosis.
  • Pin1 expression was also studied in the adult zebrafish brain.

Conclusions:

  • Specific regulatory mechanisms govern Pin1 function in a cell-type-dependent manner in vivo.
  • Zebrafish serve as a valuable model for studying Pin1's in vivo roles.
  • Understanding Pin1 regulation is crucial for comprehending its involvement in development and disease.