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Schrödinger's code-script: not a genetic cipher but a code of development.

A E Walsby1, M J S Hodge2

  • 1University of Bristol, BS8 1TH, UK.

Studies in History and Philosophy of Biological and Biomedical Sciences
|April 21, 2017
PubMed
Summary
This summary is machine-generated.

Erwin Schrödinger

Keywords:
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Area of Science:

  • Genetics
  • Molecular Biology
  • Developmental Biology

Background:

  • Erwin Schrödinger's "What is Life?" introduced the term 'code-script', a concept potentially foreshadowing the genetic code.
  • The term 'code' has multiple meanings, including 'cipher-code', 'word-code', and 'rule-code', each relevant to understanding biological information transfer.

Purpose of the Study:

  • To analyze the etymological meanings of 'code' in relation to Schrödinger's 'code-script'.
  • To differentiate between cipher-codes and rule-codes in biological contexts.
  • To propose that Schrödinger's 'code-script' aligns with a 'rule-code' model for organismal development.

Main Methods:

  • Analysis of Schrödinger's writings on 'code-script'.
  • Distinguishing between different types of codes (cipher, word, rule).
  • Comparing Schrödinger's concept with the modern understanding of the genetic code and developmental biology.

Main Results:

  • Schrödinger's 'code-script' concept evolved from protein-based genes to a hypothetical 'aperiodic solid'.
  • Schrödinger's reference to Morse code (a cipher) may have misled interpretations of his 'code-script'.
  • The genetic code involves two cipher-codes: DNA base-pairing and nucleotide-amino-acid translation.

Conclusions:

  • Schrödinger's 'code-script' is best understood as a 'rule-code', not a cipher-code.
  • Modern biological development relies on a 'rule-code' governing protein synthesis, folding, and interactions.
  • This rule-code dictates organismal development through complex protein functions.