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Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications

Ondrej Zenata1, Radim Vrzal1

  • 1Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Olomouc, Czech Republic.

Oncotarget
|April 22, 2017
PubMed

Insights

This review summarizes how Vitamin D Receptor (VDR) modifications affect its function. Understanding these post-transcriptional and post-translational changes is crucial for VDR

Area of Science:

  • Molecular Biology
  • Endocrinology
  • Pharmacology

Background:

  • The Vitamin D Receptor (VDR) is a nuclear receptor crucial for calcium and phosphate homeostasis.
  • VDR regulates cellular processes like growth, differentiation, and apoptosis.
  • VDR also influences the expression of drug-metabolizing enzymes, highlighting its clinical significance.

Purpose of the Study:

  • To review current knowledge on VDR.
  • To focus on post-transcriptional and post-translational modifications of VDR.

Main Methods:

  • Literature review of existing studies on VDR modifications.

Main Results:

  • Post-translational modifications are key to modulating VDR activity.
  • These modifications impact VDR's ability to regulate gene expression.

Conclusions:

  • Understanding VDR modifications is essential for its clinical applications.
  • Further research into VDR modifications can reveal new therapeutic strategies.
Keywords:
miRNAphosphorylation, ubiquitination, sumoylation, VDRB1, VDRA

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