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Corneal endothelial changes in long-term cannabinoid users.

Nihat Polat1, Birgul Cumurcu2, Tongabay Cumurcu1

  • 1a Department of Ophthalmology , Faculty of Medicine, Inonu University , Malatya , Turkey and.

Cutaneous and Ocular Toxicology
|April 22, 2017
PubMed
Summary
This summary is machine-generated.

Long-term cannabis use significantly decreases corneal endothelial cell density in individuals with cannabinoid use disorder. This study highlights potential ocular health risks associated with chronic cannabis consumption.

Keywords:
Cannabinoidscorneaendothelial cellsspecular microscopytoxicity

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Area of Science:

  • Ophthalmology
  • Pharmacology
  • Cell Biology

Background:

  • Cannabis use is prevalent globally, with increasing reports of long-term use.
  • Potential ocular side effects of cannabis use require thorough investigation.
  • Corneal endothelial cells are vital for maintaining corneal clarity and function.

Purpose of the Study:

  • To evaluate the impact of long-term cannabis use on corneal endothelial cell parameters.
  • To compare corneal endothelial cell density (CD), coefficient of variation (CV), and hexagonal cell ratio (HEX) between cannabis users and a control group.

Main Methods:

  • Specular microscopy was used to analyze 28 eyes of patients with diagnosed cannabinoid use disorder (cannabis group).
  • Patients in the cannabis group used cannabis at least three days per week for over one year.
  • A control group of 32 healthy individuals, matched for age and sex, was included for comparison.

Main Results:

  • A statistically significant decrease in corneal endothelial cell density (CD) was observed in the cannabis group (2900 ± 211 cells/mm²) compared to the control group (3097 ± 214 cells/mm²; p < 0.01).
  • No significant differences were found in the coefficient of variation (CV) or hexagonal cell ratio (HEX) between the cannabis users and the control group.

Conclusions:

  • Long-term cannabis use is associated with a significant reduction in corneal endothelial cell density.
  • Further research is warranted to understand the mechanisms behind this observed decrease and its clinical implications for ocular health.