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Glial Cells

Glial Cells

Nervous Tissue: Glial Cells

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...

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Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

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Published on: February 22, 2015

Central nervous system gliomas.

Michele Reni¹, Elena Mazza¹, Silvia Zanon¹

¹IRCCS Ospedale San Raffaele, Milan, Italy.

Critical Reviews in Oncology/Hematology

|April 22, 2017

Summary

This summary is machine-generated.

This study outlines practical guidelines for adult brain tumors, focusing on diagnosis, prognosis, and treatment. Key recommendations include surgical resection followed by tailored radiotherapy and chemotherapy, considering patient factors and potential long-term cognitive effects.

Keywords:

Anaplastic glioma Brain tumors Ependymoma Glioblastoma

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Area of Science:

Neuro-oncology
Clinical Neurology
Cancer Treatment Guidelines

Background:

Malignant glial tumors and ependymal tumors are frequent adult brain tumors in Europe.
Glioblastoma multiforme and anaplastic glioma are the most common gliomas, with generally poor prognoses.
Environmental and genetic factors are linked to increased brain tumor risk.

Purpose of the Study:

To delineate evidence-based practical guidelines for the diagnosis, prognosis, and treatment of common adult brain tumors.
To provide a framework for managing primary and recurrent/progressive brain tumor cases.
To emphasize the importance of considering neurocognitive function in long-term survivors.

Main Methods:

Review and synthesis of evidence-based practices for adult brain tumor management.
Integration of diagnostic, prognostic, and therapeutic strategies.
Consideration of patient-specific factors including age, performance status, histopathology, molecular markers, and prior treatments.

Main Results:

Surgical resection is the primary treatment for all brain tumor histotypes.
Radiotherapy and chemotherapy roles and timing are individualized based on patient and tumor characteristics.
Treatment decisions for recurrent or progressive disease require a multidisciplinary approach.

Conclusions:

Guidelines emphasize personalized treatment strategies for adult brain tumors.
Multifactorial patient assessment is crucial for optimizing outcomes.
Long-term neurocognitive and neuropsychological function must be addressed in survivorship care planning.