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Increased incidence and prevalence of psoriasis in multiple sclerosis

Ruth Ann Marrie1, Scott B Patten2, Helen Tremlett3

  • 1Department of Internal Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Department of Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

Multiple Sclerosis and Related Disorders
|April 22, 2017
PubMed
Abstract

Insights

People with multiple sclerosis (MS) have a higher incidence and prevalence of psoriasis. This study found a 54% increased risk of developing psoriasis in the MS population.

Area of Science:

  • Neurology
  • Dermatology
  • Epidemiology

Background:

  • Psoriasis and multiple sclerosis (MS) share risk factors, suggesting common pathogenesis.
  • Fumarates are treatments for both conditions, further supporting shared pathways.
  • Previous findings on psoriasis occurrence in MS patients are inconsistent.

Purpose of the Study:

  • To estimate and compare the incidence and prevalence of psoriasis in individuals with MS versus a matched general population cohort.
  • To investigate the association between MS and psoriasis risk.

Main Methods:

  • Population-based administrative data from Manitoba, Canada, were used.
  • 4,911 individuals with MS and 23,274 matched controls were identified.
  • Psoriasis case definitions were developed using ICD codes and prescription claims, validated against self-reports. Multivariable Cox regression analyzed psoriasis risk in the MS population.

Main Results:

  • In 2008, psoriasis incidence was 466.7 per 100,000 person-years in the MS population vs. 221.3 in controls.
  • Psoriasis prevalence in 2008 was 4666.1 per 100,000 persons in the MS population vs. 3313.5 in controls.
  • The adjusted risk of incident psoriasis was 54% higher in the MS population (HR 1.54).

Conclusions:

  • Psoriasis incidence and prevalence are significantly higher in the multiple sclerosis population compared to the general population.
  • These findings highlight a potential link between MS and psoriasis, warranting further investigation into shared mechanisms.
Keywords:
IncidenceMultiple sclerosisPrevalencePsoriasisValidation

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