Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
Cancer Vaccines01:30

Cancer Vaccines

1.2K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Gene Therapy00:59

Gene Therapy

27.8K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.8K
Cancer02:18

Cancer

55.2K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
55.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancement of ferroptosis in escape variant tumor cells by IFN-γ derived from antigen-specific T cells controls tumor with heterogeneity.

Cancer immunology research·2026
Same author

Complete Structure and Total Synthesis of Streptospherin A, a Cancer Stem Cell Inhibitor.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

[Pharmacotherapy Study of Ophthalmic Solutions and Their Contribution to Patients with Eye Diseases].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2025
Same author

Quantification of Electronic Asymmetry: Chirality and Axiality in Solids.

Physical review letters·2025
Same author

Isolation and structure determination of streptospherins B-F, novel cancer stem cell inhibitors, produced by Streptomyces sp. KUSC-240.

The Journal of antibiotics·2025
Same author

Streptospherin A, a New Cancer Stem Cell Inhibitor, Produced by Streptomyces sp. KUSC-240.

Chemical & pharmaceutical bulletin·2025

Related Experiment Video

Updated: Mar 3, 2026

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
06:10

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

1.0K

[Cancer Immunotherapy Utilizing T Cell Receptor Gene Engineering].

Hiroaki Ikeda1

  • 1Dept. of Oncology, Nagasaki University Graduate School of Biomedical Sciences.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|April 22, 2017
PubMed
Summary

New T cell therapies offer hope for cancer patients resistant to immune-checkpoint inhibitors. This approach engineers T cells with specific receptors for broader cancer treatment potential.

Area of Science:

  • Oncology
  • Immunology
  • Biotechnology

Background:

  • Immune-checkpoint inhibitors (ICIs) show efficacy in some advanced cancers, but response rates are limited (10-40%).
  • A significant unmet need exists for alternative therapies in patients resistant to ICIs.
  • Adoptive T cell therapy, particularly with engineered T cell receptors (TCRs), presents a promising alternative.

Purpose of the Study:

  • To review the clinical progress of T cell receptor (TCR)-gene engineered T cell therapy in cancer immunotherapy.
  • To discuss current challenges and future directions for enhancing the safety and efficacy of TCR-T cell therapy.

Main Methods:

  • Review of recent clinical trials and research on TCR-gene engineered T cell therapy.
  • Analysis of the potential and limitations of TCR-T cell therapy across various cancer types.

More Related Videos

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
09:56

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

Published on: February 21, 2025

1.5K
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
12:55

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

22.1K

Related Experiment Videos

Last Updated: Mar 3, 2026

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
06:10

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

1.0K
A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
09:56

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

Published on: February 21, 2025

1.5K
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
12:55

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

22.1K

Main Results:

  • TCR-gene engineered T cell therapy is emerging as a potent immunotherapy strategy.
  • This approach holds promise as a universal therapy applicable to diverse cancers.
  • Clinical development is ongoing, with significant advancements reported.

Conclusions:

  • TCR-T cell therapy is a promising next-generation cancer immunotherapy for ICI-resistant patients.
  • Further research is needed to optimize safety and broaden applicability for widespread clinical use.
  • Engineering T cells with specific TCRs offers a pathway towards more effective and universal cancer treatment.