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Related Experiment Videos

Fluorogen-free aggregation induced NIR emission from gold nanoparticles.

Meenaxi Saini1, Yogeshwar Masirkar, Ritu Varshney

  • 1Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India. sadhufcy@iitr.ac.in.

Chemical Communications (Cambridge, England)
|April 22, 2017
PubMed
Summary

Controlled addition of aqua regia induces near-infrared (NIR) luminescence in aggregated gold nanoparticles. These nontoxic nanoparticles show potential for bioimaging applications in cancer cells.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Imaging

Background:

  • Gold nanoparticles (AuNPs) are widely studied for their unique optical properties.
  • Developing novel luminescence probes for bioimaging remains a key challenge.
  • Controlling nanoparticle aggregation is crucial for tuning their optical responses.

Purpose of the Study:

  • To investigate the induction of near-infrared (NIR) luminescence in aggregated gold nanoparticles.
  • To explore the potential of these luminescent nanoparticles for bioimaging applications.

Main Methods:

  • Controlled addition of diluted aqua regia to gold nanoparticle solutions.
  • Characterization of luminescence properties using spectroscopy.
  • Assessment of nanoparticle cytotoxicity.

Related Experiment Videos

  • In vitro bioimaging studies using human liver carcinoma cells.

    • Main Results:

    • NIR luminescence was successfully induced at 916 nm in aggregated gold nanoparticles.
    • This 'turn-on' luminescence was observed irrespective of the reductants used during nanoparticle synthesis.
    • The aggregated gold nanoparticles exhibited low toxicity.
    • Effective bioimaging of human liver carcinoma cells was demonstrated using these nanoparticles.

    Conclusions:

    • Controlled aqua regia treatment is an effective method to induce NIR luminescence in aggregated gold nanoparticles.
    • These luminescent, nontoxic gold nanoparticles represent a promising platform for biomedical imaging, particularly in oncology.
    • The findings open avenues for developing new optical imaging agents based on gold nanoparticles.