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Published on: November 30, 2022
Vanadium(V)-Induced Oxidative Cross-Coupling of Various Boron and Silyl Enolates
Toru Amaya1, Yuma Osafune1, Yusuke Maegawa1
1Graduate School of Engineering, Department of Applied Chemistry, Osaka University, Yamada-oka, Suita, Osaka, 565-0871, Japan.
Abstract:
Intermolecular oxidative cross-coupling of two different enolates is one of the most useful reactions to synthesize unsymmetrical 1,4-dicarbonyl compounds. In this study, the oxovanadium(V)-induced intermolecular oxidative cross-coupling of enolates afforded unsymmetrical 1,4-dicarbonyl compounds. Various boron and silyl enolates underwent the formation of ketone-ester, ester-ketone, ester-ester, amide-ketone and amide-ester coupling products . These results clearly show the versatility of the present oxidative cross-coupling protocol.
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