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Related Concept Videos

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Related Experiment Video

Updated: Mar 3, 2026

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A mouse tissue transcription factor atlas.

Quan Zhou1, Mingwei Liu1, Xia Xia1

  • 1State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine; National Center for Protein Sciences (The PHOENIX Center, Beijing), Beijing 102206, China.

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|April 22, 2017
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Summary

This study profiles activated transcription factors (TFs) across mouse tissues, identifying 941 TFs. The findings reveal TF networks crucial for tissue maintenance and understanding diseases.

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Area of Science:

  • Molecular Biology
  • Genomics
  • Proteomics

Background:

  • Transcription factors (TFs) are critical regulators of diverse biological processes, including development and disease.
  • Understanding the landscape of activated TFs in different tissues is essential for deciphering gene regulation.

Purpose of the Study:

  • To quantitatively profile activated transcription factors (TFs) across multiple adult and fetal mouse tissues.
  • To construct a comprehensive TF network in major mouse organs using an integrated omics approach.
  • To provide a foundational dataset for understanding TF roles in tissue specificity, physiological systems, and TF-regulated diseases.

Main Methods:

  • Utilized a concatenated tandem array of consensus TF response elements (catTFRE) approach.
  • Performed proteome-scale profiling of activated TFs in 24 adult and 8 fetal mouse tissues.
  • Integrated omics data to build a TF network.

Main Results:

  • Quantitatively identified 941 transcription factors (TFs), representing over 60% of those in the mouse genome.
  • Established a TF network map for major mouse organs.
  • Characterized TF roles in tissue maintenance and physiological system features.

Conclusions:

  • The study provides an unprecedented landscape of TFs in mouse tissues.
  • The generated TF network facilitates data mining for elucidating TF functions in biological processes.
  • This resource serves as a baseline for understanding TF-mediated diseases and transcriptional regulation.