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Updated: Mar 3, 2026
Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Interleukin-6 and resistin in relation to anthropometric measurements in school children
Insights
Childhood obesity is rising, increasing metabolic disease risks. Waist circumference and waist-to-height ratio in children correlate with higher IL-6 and resistin levels, indicating early metabolic risk detection.
Area of Science:
- Pediatric Endocrinology
- Metabolic Health
- Obesity Research
Background:
- Global rise in childhood obesity over three decades.
- Obesity epidemic linked to increased type 2 diabetes and metabolic disorders in children.
- Adipokine dysregulation from excess adipose tissue contributes to metabolic diseases.
Purpose of the Study:
- To determine serum levels of interleukin-6 (IL-6) and resistin.
- To assess the relationship between these adipokines and anthropometric measurements in school children.
Main Methods:
- Study included 103 school-age children.
- Anthropometric measurements: weight, height, triceps skinfold (TSF), waist circumference (WC), waist-to-height ratio (WiHtR), Body Mass Index (BMI).
- Serum IL-6 and resistin measured via ELISA; data analyzed using SPSS (p<0.05 significance).
Main Results:
- 15.54% of children were overweight, 11.65% obese based on BMI.
- Elevated WC, WiHtR, and BMI correlated with higher IL-6 levels.
- Elevated WC and WiHtR correlated with higher resistin levels (p<0.05).
Conclusions:
- Waist circumference (WC) and waist-to-height ratio (WiHtR) are effective anthropometric indicators in children.
- These indicators aid in early detection and prognosis of metabolic risks.
- Positive correlation with pro-inflammatory cytokines (IL-6, resistin) highlights their role in pediatric metabolic health.
Abstract:
The worldwide prevalence of childhood obesity has increased greatly over the past three decades. The increasing occurrence in children of disorders, such as type 2 diabetes, is believed to be a consequence of this obesity epidemic. Although the precise mechanisms are still unclear, dysregulated production or secretion of adipokines caused by excess adipose tissue and adipose tissue dysfunction can contribute to the development of obesity-related me- tabolic diseases. The objective of the study was to determine the serum levels of interleukin-6 and resistin in relation to anthropometric measurements in school children. One hundred and three school-age children were studied. The anthropometric assessment included weight, hei- ght, triceps skinfold (TSF), waist circumference (WC), waist-to-height ratio (WiHtR) and Body Mass Index (BMI). Interleukin-6 and resistin levels were measured by ELISA. The data were analyzed using the SPSS version 20 statistical program and 95% CIs (p<0.05) was considelred significant. BMI values indicated that 15.54 % of the population was overweight, and 11.65 % was obese. We found that scholars with excess WC, WHtR and BMI (overweight) had higher levels of IL-6 and scholars with excess WC and WHtR had higher levels of resistin (p <0.05). Interleukin-6 showed positive correlation with WC (r=0.229; p = 0.020) and waist-to-height ratio (r=0.397; p
