Chondro-keratoprosthesis: an alternative to OOKP?

Area of Science:

• Ophthalmology
• Regenerative Medicine
• Biomaterials Science

Background:

• Keratoprosthesis surgery aims to restore vision in severe corneal blindness.
• Traditional osteo-odontal grafts present surgical challenges and limitations.
• Exploring alternative graft materials is crucial for improving outcomes.

Observation:

• A modified osteo-odontal keratoprosthesis procedure utilizing autologous auricular conchal cartilage graft (ACCG) was performed.
• The technique involves embedding an optical polymethyl-methacrylate cylinder within a double-layered cartilage fragment.
• The composite graft was implanted in two patients with severe vision loss.

Findings:

• One patient achieved a visual acuity of 20/100 J6 after chondro-keratoprosthesis (CKPRO) surgery.
• No major postoperative complications like extrusion or infection were observed in either case.
• The other patient's vision remained light perception due to preoperative retinal issues.

Implications:

• ACCG presents a viable alternative to traditional osteo-odontal grafts in keratoprosthesis.
• Further research with larger cohorts and extended follow-up is necessary.
• This approach may offer a new avenue for vision restoration in complex corneal diseases.