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SNM1B/Apollo in the DNA damage response and telomere maintenance
Maren Schmiester1,2, Ilja Demuth1,2,3
1Lipid Clinic at the Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
Oncotarget
|April 22, 2017
Summary
Human SNM1B/Apollo protein is crucial for DNA repair and telomere maintenance. This review summarizes its roles in DNA damage response, replication, and telomere protection, highlighting its potential involvement in human diseases.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- hSNM1B/Apollo is a conserved protein in the β-CASP subgroup of the MBL superfamily.
- It interacts with DNA repair proteins and is involved in the Fanconi anemia pathway.
- hSNM1B/Apollo functions as a shelterin accessory protein, essential for telomere maintenance.
Purpose of the Study:
- To review the known functions of hSNM1B/Apollo.
- To summarize its roles in DNA damage signaling, replication fork maintenance, and telomere protection.
- To highlight the protein's potential involvement in human diseases.
Main Methods:
- Literature review of studies on hSNM1B/Apollo.
- Analysis of protein interactions and pathway involvement.
- Examination of data related to DNA repair and telomere biology.
Main Results:
- hSNM1B/Apollo plays a key role in responding to DNA interstrand crosslinks.
- It is vital for generating and maintaining telomeric overhangs.
- The protein is implicated in DNA damage signaling and replication fork stability.
Conclusions:
- hSNM1B/Apollo is a multifunctional protein critical for genome stability.
- Its roles extend from DNA repair to telomere maintenance.
- Further research is warranted to fully elucidate its role in human disease.