Related Experiment Videos
Vascular endothelial growth factor A polymorphisms are associated with increased risk of coronary heart disease: a
Yafeng Wang1, Qiuyu Huang2, Jianchao Liu3
1Cardiovascular Department, The Second Clinical Medical College of Fujian Medical University, Quanzhou, Fujian, China.
Insights
Genetic variations in vascular endothelial growth factor (VEGFA) are linked to coronary heart disease (CHD) risk. Specific VEGFA polymorphisms (rs699947, rs3025039, rs2010963) were identified as significant risk factors for developing CHD.
Area of Science:
- Cardiovascular Genetics
- Molecular Epidemiology
- Biomedical Research
Background:
- Coronary heart disease (CHD) arises from complex genetic and environmental interactions.
- Vascular Endothelial Growth Factor (VEGFA) plays a crucial role in vascular biology.
- Identifying genetic risk factors for CHD is vital for understanding disease pathogenesis.
Purpose of the Study:
- To investigate the association between specific VEGFA gene polymorphisms (rs699947 C>A, rs3025039 C>T, rs2010963 G>C) and the risk of developing CHD.
- To conduct a comprehensive meta-analysis to pool existing evidence on VEGFA polymorphisms and CHD risk.
- To explore potential ethnic and CHD subtype-specific associations.
Main Methods:
- Systematic literature search of EMBASE and PubMed databases.
- Meta-analysis of ten publications comprising 22 trials.
- Inclusion of 2097 cases and 2867 controls.
- Calculation of Odds Ratios (ORs) with 95% Confidence Intervals (CIs) to assess genetic associations.
Main Results:
- A significant association was found between VEGFA rs699947 C>A polymorphism and increased CHD risk.
- VEGFA rs3025039 C>T polymorphism also showed a significant association with CHD risk.
- VEGFA rs2010963 G>C polymorphism was associated with myocardial infarction (MI) risk.
Conclusions:
- The VEGFA rs699947 C>A, rs3025039 C>T, and rs2010963 G>C polymorphisms are identified as risk factors for CHD.
- These findings highlight the role of VEGFA genetic variations in CHD susceptibility.
- Further large-scale, well-designed studies are recommended to validate these genetic associations.
Abstract:
Coronary heart disease (CHD) is a common complex disease resulting from the interaction of multiple environmental and genetic factors. To assess the potential relationship of vascular endothelial growth factor (VEGFA) rs699947 C>A, rs3025039 C>T and rs2010963 G>C polymorphisms with CHD risk, a comprehensive meta-analysis was conducted. A systematic search of EMBASE and PubMed online database for publications on VEGFA polymorphisms and risk of CHD was carried out. Crude Odds ratios (ORs) with their 95% confidence intervals (CIs) were calculated to determine the association. A total of ten publications including 22 trails involving 2097 cases and 2867 controls were included in our pooled analysis. Overall, results of the present meta-analysis demonstrated a significant association between VEGFA rs699947 C>A polymorphism and an increased risk of CHD. After stratifying by ethnicity and CHD type, the association was also obtained. A significant association between VEGFA rs3025039 C>T polymorphism and risk of CHD was also found. For VEGFA rs2010963 G>C polymorphism, the polymorphism was associated with MI risk. In conclusion, our findings suggest that VEGFA rs699947 C>A, rs3025039 C>T and rs2010963 G>C polymorphisms are risk factors for CHD. In the future, large sample size and well-designed epidemiologic studies are needed to confirm these conclusions.