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Does pregnancy influence melanoma prognosis? A meta-analysis
Athanassios Kyrgidis1, Aimilios Lallas, Elvira Moscarella
1aSkin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia bDepartment of Anesthesiology, Surgery and Emergency cDermatology Unit, Second University of Naples, Naples, Italy.
Pregnancy-associated melanoma (PAM) is linked to a 17% higher mortality and 50% increased recurrence risk compared to melanoma in non-pregnant women. Early detection of PAM is crucial for better patient outcomes.
Area of Science:
- Oncology
- Dermatology
- Reproductive Medicine
Background:
- The impact of pregnancy on melanoma prognosis remains unclear in existing literature.
- Pregnancy-associated melanoma (PAM) refers to melanoma diagnosed during pregnancy or postpartum.
Purpose of the Study:
- To compare the prognosis of PAM with melanoma in non-pregnant female patients.
- To evaluate survival outcomes and recurrence rates for PAM.
Main Methods:
- Systematic literature search for studies on female melanoma patients with survival outcome data.
- Meta-analysis of 15 eligible studies to assess mortality and recurrence risks.
Main Results:
- PAM showed a 17% higher mortality rate (HR=1.17, P=0.02) compared to non-pregnant controls.
- PAM was associated with a 50% higher recurrence rate (HR=1.50, P<0.001).
- Moderate heterogeneity was observed for mortality, low for recurrence.
Conclusions:
- PAM is associated with a worse prognosis, including reduced overall and disease-free survival.
- Healthcare professionals should exercise heightened awareness for PAM detection.
- Future studies are anticipated to further elucidate survival differences.
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