Related Experiment Video

Updated: Mar 3, 2026

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

4.9K

Electrocardiographic Left Ventricular Hypertrophy Predicts Cardiovascular Morbidity and Mortality in Hypertensive

Casper N Bang1,2, Elsayed Z Soliman3, Lara M Simpson4

  • 1Division of Cardiology, Department of Medicine, Weill Cornell Medical College, New York, New York, USA.

American Journal of Hypertension
|April 22, 2017
PubMed

Insights

Electrocardiographic left ventricular hypertrophy (LVH) predicts cardiovascular risks in treated hypertensive patients. This study confirms its association with increased mortality and morbidity, regardless of treatment.

Area of Science:

  • Cardiology
  • Hypertension Management
  • Diagnostic Electrocardiography

Background:

  • Electrocardiographic left ventricular hypertrophy (LVH) is a known predictor of cardiovascular (CV) morbidity and mortality.
  • The prognostic significance of ECG LVH in patients with treated hypertension requires further clarification.

Purpose of the Study:

  • To investigate the predictive value of ECG LVH for CV outcomes in a large cohort of treated hypertensive patients.
  • To determine if baseline ECG LVH is associated with all-cause mortality and secondary CV endpoints.

Main Methods:

  • A randomized trial involving 33,357 hypertensive patients (age ≥ 55) with at least one CHD risk factor.
  • Patients were randomized to chlorthalidone, amlodipine, or lisinopril.
  • ECG LVH was defined by Cornell voltage criteria; outcomes included all-cause mortality, CHD, MI, stroke, angina, HF, and PAD.

Main Results:

  • Baseline ECG LVH was identified in 7% of 26,384 patients, who were older, more likely female, and had higher systolic blood pressure.
  • During a mean follow-up of 5.0 years, baseline and in-study ECG LVH showed significant associations with increased risks (29-98%) of mortality, MI, CHD, stroke, and HF.
  • These associations remained significant in multivariable Cox analyses.

Conclusions:

  • Baseline Cornell voltage LVH is a significant independent predictor of increased CV morbidity and all-cause mortality in treated hypertensive individuals.
  • The findings highlight the importance of ECG LVH as a risk marker in this patient population, irrespective of antihypertensive treatment.
Abstract

Keywords:
Cornell voltageblood pressureelectrocardiographic left ventricular hypertrophyhypertension

More Related Videos

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.7K
Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

3.5K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
578
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
686
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.1K
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
701
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.2K
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
760